IMEDEEN Time Perfection^TM - CLINICAL AND SCIENTIFIC STUDIES

CLINICAL STUDY ON IMEDEEN TIME PERFECTION - STEPHENS & ASSOCIATES, DALLAS, TEXAS, USA
In order to quantify the benefits of Imedeen Time Perfection in improving skin tone, texture and appearance, a twelve-week double-blind, placebo controlled clinical efficacy study on 74 women was conducted by renowned US clinical investigator, Dr Monya L Sigler. The results of both the objective measurements by dermatologists and the self-assessment by participants were extremely impressive. The report concluded that when two tablets were taken daily for 12 weeks, Imedeen Time Perfection proved to be highly effective in improving the skin’s overall appearance and condition with the active tablet outperforming the placebo. The results of all scientific and clinical studies clearly show that Imedeen Time Perfection:

• Reduces the appearance of fine lines and wrinkles
• Improves skin quality and moisture balance
• Helps protect collagen and elastin fibres against harmful UV rays
• Makes skin on face and body feel softer and more supple

“The efficacy of Imedeen Time Perfection was tested under rigorous conditions and the results were very impressive. The Imedeen product showed statistically significant improvements over placebo for the Investigator’s clinical grading, instrumental measurements and the women’s own evaluation. These results are among the best that I have seen”.

DOCUMENTED RESULTS:
Abstract and Oral presentation: A placebo controlled study of an oral supplement (Imedeen Time Perfection®) in improving the appearance of photodamaged skin. EADV 2003, October 16^th -18^th, Barcelona.

Abstract and Poster presentation: A randomized, placebo controlled, double blinded study of Imedeen time perfection ^tm oral supplement in improving the appearance of photoaged skin. SCC2003, December 4^th -6^th , New York.

Abstract and Poster presentation: A Placebo controlled study of an Oral Supplement in Improving the Appearance of Photoaged Skin Improvement. AAD 2004, February 6^th – 10^th , Washington DC.

SCIENTIFIC STUDY ON IMEDEEN TIME PERFECTION - DR ODILE DAMOUR – LABORATORY FOR SKIN SUBSTITUTES, LYON, FRANCE

The technique of growing a fully developed 3-D skin equivalent in a laboratory environment was perfected by renowned French scientist, Dr Odile Damour and is widely used for testing the mode of action of various skincare ingredients and products.

In the study, Imedeen Time Perfection active ingredients were used in the same ratio as in the original tablet to feed the skin cells of the skin equivalent. The effects of the ingredients were measured and compared to the control cultures which had been developed in parallel without supplementation.

The results were impressive. Compared to the controls, the skin equivalent supplemented with Imedeen Time Perfection ingredients showed a substantial increase in the density of the dermis. Detailed investigation also showed an increased amount of protein fibres - the elements that give skin its strength and elasticity.

“In all the years I have been developing ‘in-vitro’ skin cultures, the dermal structure achieved after the addition of the Imedeen Time Perfection ingredients was among the best ever observed”.

DOCUMENTED RESULTS:
Abstract and Poster presentation: Improvement of dermal extracellular matrix structure and composition after treatment with Imedeen Time Perfection in an in vitro skin equivalent . Bouez C, Damour O, Vicanova J. 1st Joint Meeting of International Society for Bioengineering and the Skin & International Society for Skin Imaging. Hamburg, 21 - 24 May 2003.